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目的:探讨雷公藤多苷联合糖皮质激素治疗儿童紫癜性肾炎的临床疗效及安全性。方法:选择2009年8月～2011年2月在我院儿科就诊并确诊为紫癜性肾炎的104例患儿,采用随机数字表法随机分成治疗组和对照组,所有病例均采用常规综合治疗(泼尼松、双嘧达莫、维生素C、抗过敏药物及钙剂等),其中泼尼松按1.5～2 mg/(kg.d),分次口服,2～4周后据尿常规的变化逐渐减量至总疗程2～3个月停药,治疗组在此基础上加用雷公藤多苷1 mg/(kg.d),分3次口服,总疗程3～6个月,观察并记录两组患儿的临床疗效及可能的不良反应。结果:加用雷公藤多苷的治疗组总有效率96.00%,对照组总有效率81.48%,两组总有效率比较差异有统计学意义(P<0.05),未见明显不良反应。结论:小剂量雷公藤多苷联合糖皮质激素治疗儿童紫癜性肾炎临床疗效显著,复发率低,未见明显毒副作用,值得临床应用。
Objective: To investigate the clinical efficacy and safety of tripterygium glycosides combined with glucocorticoid in the treatment of purpuric nephritis in children. Methods: A total of 104 children with purpuric nephritis who were diagnosed as pediatric nephritis from August 2009 to February 2011 were randomly divided into treatment group and control group by random number table. All cases were treated by conventional combined therapy Prednisone, dipyridamole, vitamin C, anti-allergy drugs and calcium, etc.), of which prednisone at 1.5 ~ 2 mg / (kg.d), oral administration in two to four weeks according to urinary routine Changes gradually tapering to the total course of treatment of 2 to 3 months withdrawal, the treatment group on this basis plus tripterygium glycosides 1 mg / (kg.d), 3 times orally, the total course of 3 to 6 months, observed The clinical efficacy and possible adverse reactions in both groups were recorded. Results: The total effective rate was 96.00% in the treatment group and 81.48% in the control group. There was significant difference between the two groups in total effective rate (P <0.05). No obvious adverse reactions were observed. Conclusion: Low dose of tripterygium glycosides combined with glucocorticoid treatment of children with purpura nephritis clinical significant effect, low recurrence rate, no obvious side effects, it is worth clinical application.