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中科院微生物所研究员刘翠华与中国科学院院士高福、北京师范大学教授邱小波及其团队合作的一项研究揭示,结核分枝杆菌(Mtb)中分泌性酪氨酸磷酸酶(Ptp A)可通过抑制宿主天然免疫相关信号通路而促进结核分枝杆菌在巨噬细胞内的存活。研究人员还发现,结核分枝杆菌可利用宿主细胞的泛素分子进而抑制宿主的固有免疫功能。这一研究结果于2月3日在国际免疫学权威期刊《自然-免疫学》在线发表。固有免疫是机体抵抗病原微生物感染的第一道防线,其中巨噬细胞是机体识别外源病原体入侵的重要免疫细胞。结核分枝杆菌作为一种典
A study by Liu Cuihua, a researcher with the Chinese Academy of Sciences Institute of Microbiology and Gao Fu, a member of the Chinese Academy of Sciences, and professor Qiu Xiaobo from Beijing Normal University and their team revealed that secreted tyrosine phosphatase (Ptp A) in M. tuberculosis can be inhibited by inhibiting Host innate immune-related signaling pathway to promote the survival of M. tuberculosis in macrophages. The researchers also found that Mycobacterium tuberculosis can use host cell ubiquitin molecules and thus inhibit the host’s innate immune function. The results of this study on February 3 in the international authoritative journal of Immunology, “Nature - Immunology” published online. Innate immunity is the body’s first line of defense against pathogenic microorganisms, of which macrophages are important immune cells that recognize the invasion of foreign pathogens. Mycobacterium tuberculosis as a code