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目的探讨结肠透析中药保留灌肠治疗慢性肾病(CKD)临床疗效及安全性。方法将我科CKD患者63例随机分为试验组30例和对照组33例。对照组口服尿毒清颗粒及碳酸氢钠片2片/次,3次/d,口服。试验组予以结肠透析中药保留灌肠(大黄30g,蒲公英30g,生牡蛎30g)。治疗1月后评价两组疗效。结果两种治疗方案均对CKD患者有一定的临床疗效。试验组总有效率显著高于对照组,试验组血清Scr、BUN均低于对照组,差异有统计学意义(P<0.05)。结论结肠透析中药保留灌肠治疗慢性肾脏病临床有效率较高,可显著延缓患者肾功能恶化。
Objective To investigate the clinical efficacy and safety of colon dialysis with retention enema in the treatment of chronic kidney disease (CKD). Methods 63 patients with CKD in our department were randomly divided into experimental group of 30 cases and control group of 33 cases. The control group oral administration of niacin particles and sodium bicarbonate tablets 2 / times, 3 times / d, orally. The experimental group was given colon dialysis Chinese medicine retention enema (rhubarb 30g, dandelion 30g, raw oyster 30g). After 1 month of treatment, the two groups were evaluated. Results Both treatment regimens have certain clinical effect on patients with CKD. The total effective rate of the experimental group was significantly higher than that of the control group. The levels of Scr and BUN in the experimental group were significantly lower than those in the control group (P <0.05). Conclusion Colon dialysis retention enema in the treatment of chronic kidney disease clinical effective rate can significantly delay the deterioration of renal function in patients.