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为了探索槟榔添加蒌叶和石灰后对槟榔毒副作用的影响,试验向槟榔鲜果中分别添加蒌叶、石灰及其混合物,然后将KM小鼠分为5组,分别为A组(混合处理,槟榔+蒌叶+石灰)、B组(槟榔+蒌叶)、C组(槟榔+石灰)、D组(槟榔)、CK组(纯化水),并进行灌胃处理,比较分析各处理对小鼠体重、采食量、饮水量和脏器系数的影响。结果表明:用蒌叶和石灰处理可不同程度地抑制小鼠体重增加,与CK组比较差异显著;各组小鼠平均采食量和饮水量均低于CK组,且波动较大,其中A组高于其他组且波动相对较小,其次是B组;在脏器系数方面,各处理对小鼠脾脏、睾丸和心脏的影响不明显,但D组对小鼠肺脏、肝脏和肾脏的影响较大且与A组和CK组比较均差异显著,其他3组对小鼠肺脏系数影响不大,但对小鼠肾脏系数影响较大且与CK组比较均差异显著。说明用蒌叶或石灰处理或混合处理,能有效减弱槟榔对小鼠的毒副作用。
In order to explore the effect of betel nut and bentonite on betel nut toxicity after adding betel nut, the test were added to the areca nut, lime and their mixture, and then KM mice were divided into five groups, namely A group (mixed processing, areca C group (betel nut + lime), D group (betel nut), CK group (purified water), and gavage treatment. Body weight, feed intake, water intake and organ coefficient. The results showed that: the leaves and lime treatment can inhibit the body weight gain of mice in varying degrees, compared with the CK group, the difference was significant; the average feed intake and water intake of mice in each group were lower than the CK group, and the fluctuations, A Group had higher volatility than other groups, followed by group B. In terms of organ coefficient, the effect of each treatment on spleen, testis and heart was not obvious, but the effect of group D on the lung, liver and kidney of mice Larger than that of CK and CK. The other three groups had little effect on the lung coefficient of mice, but had a significant effect on the kidney coefficient of mice and had significant difference compared with CK group. Explain the use of cotyledons or lime treatment or mixed treatment, can effectively reduce the betel nut toxicity in mice.