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目的研究乳腺癌雌激素受体(ER)、孕激素受体(PR)表达与细胞核变化的关系,探讨其临床应用价值。方法选择苏州市中医院病理科2002年以来42例乳腺癌标本,总结其ER和PR表达,并作细胞核形态定量图像分析;同时与20例良性病变对比。结果乳腺癌细胞核等圆直径、面积及边缘周长,均较良性对照组为大,差别有统计学意义(P<0.01)。ER+/PR-病例细胞核形态定量与ER+/PR+比较,差别有统计学意义(P<0.05);ER-/PR-病例细胞核形态定量与ER+/PR+比较,差别有统计学意义(P<0.01)。乳腺癌ER和PR可同时或分别失表达,PR失表达病例细胞核形态变量较大,尤其ER和PR同时失表达病例细胞核形态变量更大。结论良、恶性乳腺病变细胞核形态定量差别显著,对鉴别诊断有实用价值。ER和PR的表达结合细胞核形态学测量结果对治疗和预后的评估有意义。
Objective To study the relationship between estrogen receptor (ER) and progesterone receptor (PR) expression and nuclear changes in breast cancer, and to explore its clinical application value. Methods A total of 42 breast cancer specimens from the Department of Pathology, Suzhou City Hospital of Traditional Chinese Medicine, were selected from 2002 to 2002. The ER and PR expressions were summarized and quantitative image analysis of nuclear morphology was performed. The results were compared with 20 benign lesions. Results The diameter, area and marginal perimeter of the nuclei of breast cancer cells were larger than those of the benign control group, and the difference was statistically significant (P<0.01). The quantification of nucleus morphology in ER+/PR- cases was significantly different from that of ER+/PR+ (P<0.05). The quantification of nucleus morphology in ER-/PR- cases was compared with that of ER+/PR+ (P<0.01). . The expression of ER and PR in breast cancer can be lost simultaneously or separately. The morphological variation of the karyotypic nucleus is larger in the case of loss of expression of PR, especially in the case of ER and PR loss of expression. Conclusion The quantificational differences in the nucleus morphology of benign and malignant breast lesions are significant, which has practical value in differential diagnosis. The expression of ER and PR combined with nuclear morphological measurements is meaningful for the evaluation of treatment and prognosis.