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目的测定哮喘患者血浆中内皮素(ET)、血栓素B2(TXB2)的表达水平,探讨其在哮喘发病中的作用。方法选择急性发作期哮喘患者55例(轻度32例,中、重度23例),对照组18例。用放射免疫法测定血浆中ET、TXB2的水平。结果①轻度组与中、重度组患者血浆中ET、TXB2水平高于对照组,差异有统计学意义(P<0.01);中、重度组血浆ET、TXB2水平高于轻度组,差异有统计学意义(P<0.01)。②哮喘组血浆中ET与TXB2水平呈正相关(r=0.574,P<0.01)。结论ET、TXB2可能参与哮喘的炎症过程并影响哮喘的发生、发展。
Objective To determine the plasma levels of endothelin (ET) and thromboxane B2 (TXB2) in asthmatic patients and to explore its role in the pathogenesis of asthma. Methods Fifty-five patients with acute exacerbation of asthma (32 mild, 23 moderate and severe) and 18 control subjects were selected. The levels of ET and TXB2 in plasma were determined by radioimmunoassay. Results ① The plasma levels of ET and TXB2 in mild and moderate and severe groups were significantly higher than those in control group (P <0.01). The levels of plasma ET and TXB2 in moderate and severe groups were higher than those in mild and moderate groups Statistical significance (P <0.01). ② There was a positive correlation between plasma ET and TXB2 level in asthma group (r = 0.574, P <0.01). Conclusion ET and TXB2 may participate in the inflammatory process of asthma and affect the occurrence and development of asthma.