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目的:探讨热化疗对口腔癌患者白细胞介素-2(IL-2)、肿瘤坏死因子(TNF)水平的影响。方法:回顾性分析我院2005-02/2008-08收治的23例口腔鳞癌,进行微波热疗、CPM方案化疗(卡铂、平阳霉素、甲氨蝶呤),于第一次治疗前及最后一次治疗后取其外周血行IL-2、TNF水平检测。结果:热化疗后口腔癌患者IL-2、TNF水平较治疗前明显提高,有统计学差异(P<0.01)。结论:热化疗可以提高口腔癌患者IL-2、TNF水平,从而增强机体的免疫功能,提高机体抗肿瘤效应。
Objective: To investigate the effect of thermochemotherapy on the levels of interleukin-2 (IL-2) and tumor necrosis factor (TNF) in oral cancer patients. Methods: A retrospective analysis of 23 cases of oral squamous cell carcinoma treated in our hospital from February 2005 to August 2008 was conducted with microwave hyperthermia and CPM chemotherapy (carboplatin, pingyangmycin and methotrexate). Before the first treatment And the last treatment of peripheral blood IL-2, TNF levels were detected. Results: The levels of IL-2 and TNF in patients with oral cancer after thermotherapy were significantly higher than those before treatment (P <0.01). Conclusion: Chemotherapy can improve the level of IL-2 and TNF in oral cancer patients, enhance the immune function and improve the anti-tumor effect.