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胰岛素发现已60年,其对糖尿病的治疗并未失去意义,但胰岛素治疗不能防止青少年型糖尿病多年后出现肾、血管和视网膜病变。动物实验表明胰腺移植后血清胰岛素浓度正常,可防止并消除糖尿病微血管发生病变。因此近年来胰腺移植治疗青少年型糖尿病有了发展,目前有三种方法,即全胰移植,胰节段移植和胰岛移植。三种方法都是移植足够量有功能的内分泌腺,使糖代谢恢复正常,目前胰腺移植和节段胰腺移植并发症发生率高,故胰岛移植为目前的重要研究课题。
Insulin has been found 60 years, its treatment of diabetes has not lost its meaning, but insulin therapy can not prevent juvenile diabetes years after renal, vascular and retinal lesions. Animal experiments show that normal serum insulin concentration after pancreas transplantation can prevent and eliminate the occurrence of diabetic microangiopathy. Therefore, in recent years, pancreas transplantation for the treatment of adolescent type diabetes has developed, there are three methods, namely, pancreas transplantation, pancreatic segmental graft and islet transplantation. All three methods are transplanted enough functional endocrine glands so that glucose metabolism returns to normal. At present, the incidence of pancreatic and segmental pancreas transplantation complications is high, so islet transplantation is an important research topic at present.