论文部分内容阅读
41只正常家兔,在局麻与肌松剂制动下分别用15～70μA,70Hz,1ms方波刺激下丘脑外侧区(LHA)和腹内侧核(VMH)区域,可诱发心律失常和增压反应,并存在相对特异性。刺激LHA时可诱发窦性心搏徐缓、窦性停搏和传导阻滞等慢速心律失常(Brady-arrythmias,BA),且发生率较高;刺激VMH则多见频发的室性期前收缩(Hypothalamic stimulation-induced Ventricular Extrasystoles,HVE),室性或室上性心动过速等快速心律失常(Tacky-arrythmias,TA)。静注阿托品或切断颈部双侧迷走神经干后刺激LHA或VMH则心律失常消失或阻抑。静注心得安或酚妥拉明后刺激LHA或VMH则TA消失或阻抑,而刺激LHA较VMH诱发BA更为明显。
Forty-one normal rabbits were stimulated by 15 ~ 70μA, 70Hz and 1ms square wave respectively in the LHA and VMH regions under local anesthesia and muscle relaxant to induce arrhythmia and increase Pressure response, and there is a relative specificity. Stimulation of LHA can induce slow bradyarrhythmias such as sinus bradycardia, sinus arrest, and conduction block (Bradyarrhythmias, BA), and a higher incidence; more frequent VMH stimulation of ventricular premature contractions ( Hypothalamic stimulation-induced Ventricular Extrasystoles (HVE), Tacky-arrythmias (TA), such as ventricular or supraventricular tachyarrhythmias. Intravenous atropine or cut off the bilateral vagus nerve trunk after stimulation of LHA or VMH arrhythmia disappeared or suppressed. After intravenous injection or phentolamine stimulation of LHA or VMH, TA disappeared or repressed, while stimulation of LHA was more pronounced than VMH-induced BA.