苯巴比妥是酶的诱导剂,通过诱导肝药酶促进药物代谢。但促进新斯的明代谢和在胆汁中排泄的作用,却不是通过对酶的诱导。新斯的明在体内的消除是否与苯巴比妥对胆汁流量、胆小管运输及肝血流量的影响有关,本文做推测性说明。众所周知,新斯的明在体内的代谢与其分子中的季胺结构有关,主要经肝药酶水解成3—羟基苯基3—甲胺,再被诱导成3—羟基葡萄糖醛酸甙。对苯巴比妥影响新斯的 Phenobarbital is an enzyme inducer that promotes drug metabolism by inducing hepatic drug enzymes. But the role of promoting neostigmine metabolism and excretion in bile is not through the induction of enzymes. The elimination of neostigmine in the body is related to the effect of phenobarbital on bile flow, bile duct transport, and hepatic blood flow. This article is speculative. It is well-known that the metabolism of neostigmine in the body is related to the quaternary amine structure in its molecule, which is mainly hydrolyzed by hepatic enzymes to form 3-hydroxyphenyl 3-methylamine, which is then induced into 3-hydroxyglucuronide. Effects of phenobarbital on neostigmine