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顺铂是目前临床上常用的广谱高效抗癌药,但该药具有严重的耳不良反应,可造成双侧听力损失。本文就国内外近年对顺铂耳毒性的作用机制及其防护的研究进展予以综述。
Cisplatin is the most widely used broad-spectrum anti-cancer drug currently in clinical use. However, this drug has serious adverse reactions to the ear and can cause bilateral hearing loss. This review summarizes the research progress on the mechanism and protection of cisplatin ototoxicity in recent years.