论文部分内容阅读
以格列齐特和盐酸二甲双胍为阳性对照药物,研究枇杷叶三萜酸提取物对正常小鼠空腹血糖值的影响、对正常小鼠经口葡萄糖和淀粉耐受的影响以及对糖尿病小鼠血糖的影响。结果与格列齐特相比(100 mg/kg),枇杷叶三萜酸提取物对正常小鼠的空腹血糖无明显影响(P>0.05);与格列齐特(100 mg/kg)相比,枇杷叶三萜酸提取物对四氧嘧啶所致高血糖模型小鼠的血糖值的抑制效果不明显(P>0.05);枇杷叶三帖酸粗提物(CTAL,400 mg/kg)对正常小鼠空腹灌胃葡萄糖后的血糖上升有明显的抑制作用(P<0.01),抑制效果与盐酸二甲双胍(100 mg/kg)相当,而枇杷叶科罗索酸(CAL)对此抑制活性不明显(P>0.05);枇杷叶三帖酸粗提物(CTAL,400 mg/kg)对正常小鼠空腹灌胃淀粉后的血糖上升有较强的抑制作用(P<0.01),抑制效果强于盐酸二甲双胍(100 mg/kg),而枇杷叶科罗索酸(CAL,400 mg/kg和100 mg/kg)也显示较好抑制作用(P<0.05)。枇杷叶提取物体现出较好的控制餐后血糖的活性且不对正常机体的血糖值造成影响,具有开发成减肥产品或相关药物的良好的前景。
Gliclazide and metformin hydrochloride as positive control drugs to study the loquat leaf triterpenic acid extract on normal mice fasting blood glucose value, the impact of oral glucose and starch tolerance in normal mice and diabetic mice glucose Impact. Results Compared with gliclazide (100 mg / kg), the triterpene acid extract of loquat leaf had no significant effect on fasting blood glucose in normal mice (P> 0.05) (P> 0.05). The extract of Triterpenic acid from loquat leaf (400 mg / kg) showed no significant effect on the blood glucose level of alloxan-induced hyperglycemia mice (P> 0.05) (P <0.01). The inhibitory effect was similar to that of metformin hydrochloride (100 mg / kg), while the inhibitory activity of loracolic leaf corosolic acid (CAL) (P> 0.05). The CTAL (400 mg / kg) had a strong inhibitory effect on the increase of blood glucose in normal mice (P <0.01), and the inhibitory effect Was stronger than metformin hydrochloride (100 mg / kg), while corosolic acid (CAL, 400 mg / kg and 100 mg / kg) of loquat also showed better inhibition (P <0.05). Loquat leaf extract shows good activity of controlling postprandial blood glucose without affecting the blood sugar level of normal body, and has a good prospect of developing into a weight loss product or related medicine.