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目的探讨急性心肌梗死(Acute myocardial infarction,AMI)患者溶栓治疗后血清同型半胱氨酸(Homocysteine,Hcy)水平的变化及对愈后的意义。方法应用酶连免疫法对40例急AMI患者进行了溶栓治疗前后血浆Hcy的检测,并与40例正常健康人进行比较。结果在溶栓治疗前,急性心梗患者血浆Hcy水平显著高于对照组(P<0.01);治疗后2周,则与对照组比较无显著性差异(P>0.05)。结论检测AMI患者血浆Hcy水平的变化,对了解病情、观察预后有重要的临床价值。
Objective To investigate the changes of serum homocysteine (Hcy) level after thrombolytic therapy in patients with acute myocardial infarction (AMI) and its significance to prognosis. Methods Enzyme linked immunosorbent assay was used to detect plasma Hcy in 40 patients with acute AMI before and after thrombolytic therapy and compared with 40 normal healthy subjects. Results Before the thrombolytic therapy, plasma Hcy levels in patients with acute myocardial infarction were significantly higher than those in the control group (P <0.01). There was no significant difference between the two groups after 2 weeks of treatment (P> 0.05). Conclusion The detection of plasma Hcy levels in patients with AMI, the understanding of the disease, prognosis has important clinical value.