论文部分内容阅读
目的 :探讨消溃灵对消化性溃疡愈合的影响及其胃粘膜保护作用的机制。方法 :采用大鼠乙酸性胃溃疡模型 ,分别以消溃灵灌胃和左旋精氨酸 (L- Arg)、亚硝基左旋精氨酸 (L- NNA)腹腔内注射治疗 7d和 14d后 ,测定溃疡指数、溃疡抑制率 ,检测血清一氧化氮 (NO)及血浆内皮素 (ET- 1)含量。结果 :消溃灵组溃疡指数、血浆 ET- 1含量明显降低 ,而溃疡抑制率、血清 NO含量显著升高 ,与模型组和 L- NNA组比较差异有显著性意义 (P<0 .0 1) ,与L- Arg组比较无统计学意义 (P>0 .0 5 )。L- NNA组溃疡指数、血浆 ET- 1水平显著高于模型组 (P<0 .0 1) ,而血清NO含量则明显低于模型组 (P<0 .0 1)。结论 :消溃灵促进溃疡愈合 ,保护胃粘膜的作用可能与其诱导、促进 NO合成 ,反馈性地抑制 ET- 1释放 ,维持 NO和 ET的动态平衡密切相关。
Objective: To explore the effect of Xiaokuiling on peptic ulcer healing and the protective mechanism of gastric mucosa. METHODS: Rats with acetic acid-induced gastric ulcer were treated with Xiaokeling gavage and L-arginine (L-Arg) and L-nitroarginine (L-NAA) intraperitoneally for 7d and 14d respectively. The ulcer index and ulcer inhibition rate were measured, and serum nitric oxide (NO) and plasma endothelin (ET-1) levels were measured. Results: The ulcer index and plasma ET-1 content in Xiaokuiling group decreased significantly, while the ulcer inhibition rate and serum NO content increased significantly. There was significant difference between model group and L-NAA group (P<0.01). ), compared with L-Arg group was not statistically significant (P> 0.05). The ulcer index and plasma ET-1 levels in the L-NAA group were significantly higher than those in the model group (P < 0.01), while serum NO levels were significantly lower than those in the model group (P <0.01). Conclusion : Xiaokuiling promotes ulcer healing and protects the gastric mucosa. It may induce and promote the synthesis of NO, feedback inhibit the release of ET-1, and maintain the dynamic balance of NO and ET.