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目的探讨重组人表皮生长因子(rh EGF)凝胶在尿道下裂术后尿瘘早期处理中的应用效果。方法将2011年9月至2014年7月行尿道下裂手术后出现的44例尿瘘患者随机分为2组,2组患者在给予留置尿管、常规创面换药及对症处理的基础上,试验组瘘口表面应用rh EGF凝胶,对照组瘘口表面涂以0.9%氯化钠溶液,观察2组尿瘘愈合情况。结果试验组共愈合14例,总愈合率63.64%,其中大瘘口愈合9例,小瘘口愈合5例;对照组共愈合5例,总愈合率22.73%,其中大瘘口仅愈合2例,小瘘口愈合3例。与对照组比较,试验组总愈合率和大瘘口的愈合率明显提高,差异有统计学意义(P<0.05),而小瘘口的愈合率略高于对照组,但差异无统计学意义(P>0.05)。结论尿道下裂术后尿瘘早期及时处理,小瘘口大部分能够愈合,应用rh EGF凝胶对瘘口愈合具有促进作用。
Objective To investigate the effect of recombinant human epidermal growth factor (rh EGF) gel in the early treatment of urinary fistula after hypospadias operation. Methods Forty-four patients with urinary fistula who underwent hypospadias operation from September 2011 to July 2014 were randomly divided into two groups. On the basis of catheterization, routine wound dressing and symptomatic treatment, the two groups were tested The surface of the group of fistula application of rh EGF gel, the control group was coated with 0.9% sodium chloride solution on the surface of the fistula to observe the two groups of urinary fistula healing. Results The experimental group were healed in 14 cases, the total healing rate was 63.64%, of which 9 cases of large fistula healed, 5 cases of small fistula healed; 5 cases of healing of the control group, the total healing rate of 22.73%, of which only 2 cases of large fistula healed Small fistula healed in 3 cases. Compared with the control group, the total healing rate of the experimental group and the healing rate of large fistula significantly increased, the difference was statistically significant (P <0.05), while the healing rate of small fistula was slightly higher than the control group, but the difference was not statistically significant (P> 0.05). Conclusions In the early stage of urinary fistula treatment after hypospadias surgery, most of the small fistulas healed. The application of rh EGF gel can promote the healing of fistula.