先天性巨结肠是一种以肠道末端肠壁神经节细胞完全缺如为特征的常见消化道发育畸形[1]。该病的病理改变主要在结肠远端痉挛肠段,其特征性组织学改变为肌间神经丛和黏膜下神经丛中缺乏神经节细胞,神经节细胞缺如使得肠段失去间隙性收缩和放松的正常蠕动,神经节细胞缺如还丧失了 Hirschsprung’s disease is a common developmental abnormality of the digestive tract characterized by total absence of ganglion cells in the intestinal wall at the end of the intestine [1]. The pathological changes of the disease mainly in the colon distal spastic bowel, its characteristic histological changes to the myenteric plexus and submucosal nerve plexus in the lack of ganglion cells, lack of ganglion cells caused loss of interstitial gap contraction and relaxation The normal peristalsis, loss of ganglion cells also lost