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目的 :探讨甲钴胺是否具有防治氨基甙类抗生素耳毒作用。方法 :用单次肌注大剂量庆大霉素 ( 12 5m g/ kg)造成感音障碍的动物模型。通过系列观察耳蜗电图的变化 ,观察在肌注庆大霉素的同时应用甲钴胺 ( 1m g/ kg)是否具有拮抗庆大霉素的瞬时耳毒作用。结果 :1单次大剂量庆大霉素注射 ,可引起动物复合动作电位CAP N1 ,N2 潜伏期延长与振幅减弱 ;N1 - N2 间期虽有延长 ,变化仍在正常范围内 ;2单次大剂量庆大霉素注射并与甲钴胺同时用药 ,N1 及 N2 的上述变化明显改善。结论 :甲钴胺在增强神经纤维生理功能的同时 ,尚有拮抗庆大霉素的瞬时耳毒作用 ,这可能与甲钴胺在 S-腺苷甲硫胺酸甲基化过程中产生谷胱苷肽 - SH有关
Objective: To investigate whether mecobalamin has the effect of preventing and treating ototoxicity of aminoglycosides. METHODS: Animal models of sensorineural disturbance caused by a single intramuscular injection of gentamicin (125 mg / kg). A series of observation of changes in the electrocochleogram to observe the application of mecobalamin (1m g / kg) at the same time intramuscular injection of gentamycin antagonistic gentamicin transient ototoxicity. Results: 1 A single bolus injection of gentamicin caused a prolonged latency and amplitude decrease of CAP N1 and N2 in the compound action potentials of animals. Although N1 - N2 interval prolonged, the changes were still in the normal range. 2 Single bolus Gentamycin injection and mecobalamin concurrent medication, N1 and N2 of the above changes significantly improved. CONCLUSION: Mecobalamin can antagonize the instantaneous ototoxicity of gentamicin while enhancing the physiological function of nerve fibers, which may be related to the mecobalamin producing S-adenosylmethionine methylation Glycosides - SH related