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目的观察乌司他丁治疗宫颈癌患者急性放射性肠炎的临床疗效和对炎性因子的影响,为临床急性放射性肠炎的治疗提供新的参考方案。方法选择行子宫颈恶性肿瘤根治性放疗合并急性放射性肠炎患者80例,按随机数字表法分为2组,每组40例,2组均采取常规治疗,试验组给予乌司他丁治疗,对照组给予等量生理盐水治疗。比较2组临床疗效及治疗前后血清肿瘤坏死因子α(TNF-α)、白细胞介素6(IL-6)、血清C反应蛋白(CRP)水平。结果试验组总有效率为90.0%显著高于对照组的70.0%,差异有统计学意义(χ2=6.49,P<0.05)。治疗前2组TNF-α、IL-6、CRP水平比较差异均无统计学意义(P>0.05);治疗后2组患者TNF-α、IL-6、CRP水平均显著下降,且试验组低于对照组,差异均有统计学意义(P<0.05)。结论乌司他丁治疗宫颈癌患者急性放射性肠炎具有显著治疗效果,可明显降低患者的炎性因子水平,缓解患者炎性反应,减轻患者症状,值得临床推广应用。
Objective To observe the clinical efficacy of ulinastatin in the treatment of acute radiation enteritis in patients with cervical cancer and its influence on inflammatory factors, and to provide a new reference for the treatment of acute radiation enteritis in clinical practice. Methods Eighty patients with radical radiotherapy combined with acute radiation enteritis undergoing cervical cancer were randomly divided into two groups (n = 40 in each group). The two groups were given routine treatment. The patients in the experimental group were treated with ulinastatin. The control group Group given the same amount of saline treatment. The clinical curative effect and the levels of serum tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6) and serum C-reactive protein (CRP) were compared between the two groups before and after treatment. Results The total effective rate was 90.0% in the experimental group was significantly higher than 70.0% in the control group, the difference was statistically significant (χ2 = 6.49, P <0.05). There was no significant difference in TNF-α, IL-6 and CRP levels between the two groups before treatment (P> 0.05). After treatment, the levels of TNF-α, IL-6 and CRP decreased significantly In the control group, the differences were statistically significant (P <0.05). Conclusion Ulinastatin has a significant therapeutic effect on acute radiation enteritis in patients with cervical cancer, which can significantly reduce the level of inflammatory cytokines, alleviate the inflammatory reaction and relieve the symptoms of patients, which is worthy of clinical application.