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目的:报道前列腺腺癌伴神经内分泌分化患者术后复发1例,希望能引起病理诊断医师及临床医师对前列腺腺癌是否伴有神经内分泌分化的高度重视。方法:报道我院收治的前列腺腺癌患者1例,经我科病理诊断为前列腺腺癌,Gleason 4+5=9分。8个月后该患者尿痛再次入院,手术标本经我科病理诊断为前列腺小细胞癌,Gleason 5+5=10分。结果:将第1次病理标本补做神经内分泌标记NSE、Cg A、Syn及CD56均为阳性,由此可见该患者第1次入院时前列腺腺癌已经伴有神经内分泌分化。针对该病例前列腺腺癌伴神经内分泌分化,我们查阅了相关文献,并将其病理诊断、治疗及预后因素做了总结和反思。结论:前列腺腺癌是否伴有神经内分泌分化直接关系到患者疾病的进展、预后及后期治疗方案,因此,前列腺腺癌是否伴有神经内分泌分化应该在病理诊断中予以高度重视。
OBJECTIVE: To report a case of postoperative recurrence of prostate adenocarcinoma with neuroendocrine differentiation in the hope of arousing pathological diagnosis of physicians and clinicians attached to the prostate adenocarcinoma with neuroendocrine differentiation attach great importance. Methods: One case of prostatic adenocarcinoma admitted to our hospital was diagnosed as prostate adenocarcinoma by pathology. Gleason 4 + 5 = 9 points. Eight months later, the patient was again admitted to hospital for dysuria. Surgical specimens were diagnosed as prostate small cell carcinoma by pathology. Gleason 5 + 5 = 10 points. Results: The first pathological specimens were made neuroendocrine markers NSE, Cg A, Syn and CD56 were positive, we can see the first admission of patients with prostate adenocarcinoma has been associated with neuroendocrine differentiation. For this case of prostate adenocarcinoma with neuroendocrine differentiation, we reviewed the relevant literature, and its pathological diagnosis, treatment and prognostic factors are summarized and reconsidered. Conclusion: Whether or not the prostate adenocarcinoma is associated with neuroendocrine differentiation is directly related to the disease progression, prognosis and post-operative treatment of patients. Therefore, whether or not prostate adenocarcinoma is associated with neuroendocrine differentiation should be paid more attention in the pathological diagnosis.