Objective To investigate the significance of overexpresson of cyclin D1 and P53 protein in cervical squamous cell carcinomas.Methods Fifty cases of invasive cervical squamous cell carcinomas and 10 cases of normal cervical squamous epithelia were investigated with immunihistochemical technique. Results The overexpression of cyclin D1 and P53 in invasive cervical carcinomas was 70% and 50%, respectively. There was no overexpression of them in the control group. The overexpression of cyclin D1 in grade Ⅱ and Ⅲ was much higher than that in gradeⅠ(P<0.05). The overexpresson of cyclin D1 in stage Ⅲ of cervical carcinoma was significantly higher than that in stage Ⅱ (P<0.05). The overexpression of P53 in grade Ⅱ and grade Ⅲ of cervical carcinoma was remarkably higher than that in grade Ⅰ (P<0.05).Conclusion The action point of both cyclin D1 and P53 may be at G1/S transition. The overexpression of them was associated with development and progression of cervical carcinoma probably in different mechanisms and different pathways. Objective To investigate the significance of overexpresson of cyclin D1 and P53 protein in cervical squamous cell carcinomas. Methods Fifty cases of invasive cervical squamous cell carcinomas and 10 cases of normal cervical squamous epithelia were investigated with immunihistochemical technique. Results The overexpression of cyclin D1 and P53 There was no overexpression of them in the control group. The overexpression of cyclin D1 in grade II and III was much higher than that in grade I (P <0.05). The overexpresson of The overexpression of P53 in grade Ⅱ and grade Ⅲ of cervical carcinoma was remarkably higher than that in grade Ⅰ (P <0.05) .Conclusion of cyclin D1 in stage Ⅲ of cervical carcinoma was significantly higher than that of stage Ⅱ (P <0.05) The action point of both cyclin D1 and P53 may be at G1 / S transition. The overexpression of them was associated with development and progression of cervical carcinom a probably in different mechanisms and different pathways.