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通过建立大鼠高锌（ＺＨ）模型，研究高锌对胸腺发育的影响及其作用机理。结果表明：（１）ＺＨ组的体重、体重增长值、饲料效价均非常显著低于配对（ＰＦ）组；（２）ＺＨ组的血清、毛发、股骨及胸腺细胞锌含量均非常显著地高于ＰＦ组；（３）ＺＨ组的胸腺重量、胸腺指数、胸腺细胞大小、胸腺肽含量和胸腺素活性，均非常显著地低于ＰＦ组；（４）ＺＨ组的胸腺细胞内ＤＮＡ、蛋白质含量低于，而Ｇ１／Ｇ０期细胞（％）数高于ＰＦ组；（５）ＺＨ组胸腺细胞内ｃＡＭＰ、ｃＡＭＰ／ｃＧＭＰ比值非常显著高于ＰＦ组，增殖指数（ＰＩ）与ｃＡＭＰ、ｃＡＭＰ／ｃＧＭＰ比值呈负相关；与ｃＧＭＰ呈正相关，均Ｐ＜０．０１；（６）ＺＨ组血清钙低于ＰＦ组，而胸腺细胞内Ｃａ２＋高于ＰＦ组，Ｐ＜０．０５。结果提示，适量锌有促进胸腺发育、增殖的作用，而高锌则反之。其机理可能是高锌影响细胞内腺苷酸环化酶系统，并与胞浆内游离钙和钙调蛋白的调节活性有关。
The establishment of rat high zinc (ZH) model to study the high zinc on thymus development and its mechanism of action. The results showed that: (1) The body weight, body weight gain and feed titer in ZH group were significantly lower than those in PF group. (2) The zinc content in serum, hair, femur and thymus of ZH group was significantly higher In PF group; (3) Thymus weight, thymus index, thymus, thymus and thymosin activities in ZH group were significantly lower than those in PF group; (4) The content of DNA and protein in thymus of ZH group was low (5) The ratio of cAMP and cAMP / cGMP in thymocytes of ZH group was significantly higher than that in PF group. The ratio of proliferation index (PI), cAMP and cAMP / cGMP (P <0.01). (6) Serum calcium in ZH group was lower than that in PF group, while Ca2 + in thymocytes was higher than that in PF group (P <0.05). The results suggest that the amount of zinc to promote thymic development, proliferation, while the high zinc is the opposite. The mechanism may be that high zinc affects the intracellular adenylate cyclase system and is associated with the regulatory activity of intracellular free calcium and calmodulin.