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用体内试验方法对克拉霉素胶囊的抗菌活性进行评价，并与红霉素进行比较。对4种7株致病菌感染小鼠的体内抗菌试验结果显示，克拉霉素对金黄色葡萄球菌，化脓性链球菌和肺炎双球菌敏感菌的体内保护作用是红霉素6．81～8．62倍，对耐金黄色葡萄球菌和嗜血流感杆菌的体内作用分别优于红霉素17．92倍和17倍。
The antibacterial activity of clarithromycin capsules was evaluated in vivo and compared with erythromycin. The in vivo antibacterial test results on four kinds of seven pathogenic bacteria infected mice showed that the in vivo protective effect of clarithromycin against Staphylococcus aureus, Streptococcus pyogenes and Streptococcus pneumoniae was erythromycin 6.81-8 .62 times, in vivo resistance to Staphylococcus aureus and Escherichia coli are 17.92 times and 17 times higher than that of erythromycin.