精制白喉毒素加０．０２Ｍβ—丙氨酸，再加甲醛溶液经适当的时间解毒，即可转化为完全类毒化且无毒性逆转的精制白喉类毒素。此精白类的脱毒试验、毒性逆转试验、安全试验及效力试验均符合《中国生物制品规程》要求。在脱毒过程中絮状单位的损失明显低于单纯甲醛脱毒者，纯度亦相应得到了提高。 Refined diphtheria toxin plus 0.02Mβ-alanine, plus formaldehyde solution detoxification after an appropriate time, can be converted into completely toxic and toxic reversal of free diphtheria toxoid. The virulent detoxification test, toxicity reversal test, safety test and efficacy test are in accordance with the requirements of “China Biological Products Regulations”. During the detoxification process, the flocculent unit loss was significantly lower than pure formaldehyde detoxification, the purity has also been increased accordingly.