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目的探讨原发性高血压患者补体C3的表达水平及其与载脂蛋白B(ApoB)的关系。方法 58例原发性高血压患者为观察组,48例非原发性高血压患者为对照组,比较补体C3、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(ApoA1)、ApoB等指标,分析补体C3与ApoB的关系。结果观察组补体C3、TG、TC、LDL-C、ApoB均高于对照组(P<0.05)。观察组补体C3与BMI、ApoB呈正相关(P<0.05),ApoB与补体C3、TG、TC、LDL-C呈正相关(P<0.05),多元逐步回归分析显示ApoB与补体C3互有影响。结论原发性高血压患者补体C3与ApoB具有一定的相关性。
Objective To investigate the expression of complement C3 in patients with essential hypertension and its relationship with apolipoprotein B (ApoB). Methods Fifty-eight patients with essential hypertension were divided into observation group and 48 non-essential hypertension patients as control group. Comparisons of complement C3, triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol C, LDL-C, ApoA1 and ApoB were measured to analyze the relationship between complement C3 and ApoB. Results The levels of complement C3, TG, TC, LDL-C and ApoB in observation group were higher than those in control group (P <0.05). There was a positive correlation between complement C3 and BMI and ApoB in observation group (P <0.05). ApoB was positively correlated with C3, TG, TC and LDL-C (P <0.05). Multiple stepwise regression analysis showed that ApoB and complement C3 had mutual influence. Conclusion There is a certain correlation between complement C3 and ApoB in patients with essential hypertension.