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目的探讨原发性高血压(EH)患者的左心室功能及各临床变量与瘦素受体(LR)基因Gln223Arg变异的关系。方法用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)检测了EH组90例及正常对照组52例的LR基因Gln223Arg的变异,对2组的LR基因Gln223Arg的变异进行对照分析比较。同时检测了EH组及正常对照组的左心室功能及各临床变量,并进行对照分析比较。结果LR基因Gln223Arg变异的不同基因型在EH组与正常对照组之间分布频率差异无统计学意义;EH患者的左心室功能及各临床变量的变化与LR基因Gln223Arg不同基因型相关。结论EH患者的左心室功能及各临床变量的变化与LR基因Gln223Arg的变异有关。
Objective To investigate the relationship between left ventricular function and various clinical variables in patients with essential hypertension (EH) and the mutation of leptin receptor (Gln223Arg). Methods The polymorphisms of Gln223Arg of LR gene in 90 cases of EH group and 52 cases of normal control group were detected by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and the variation of Gln223Arg in LR group was compared Compare At the same time, the left ventricular function and clinical variables of EH group and normal control group were detected and compared. Results There was no significant difference in the distribution frequencies of the Gln223Arg LR genotypes between the EH group and the normal control group. The changes of left ventricular function and clinical variables in the EH patients were related to different genotypes of Gln223Arg. Conclusion The changes of left ventricular function and clinical variables in patients with EH are related to the mutation of Gln223Arg.