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外周血液中微丝蚴(mf)的出现与体内抗丝虫的体液和细胞免疫应答的减弱有关,海群生(DEC)治疗可导致对丝虫特异性抗原反应显著增高。已知DEC杀微丝蚴作用需宿主因素参与,且有杀丝虫成虫作用。伊维菌素不同于DEC,现在认为,它直接杀mf,对成虫无作用。为此,比较上述2种药物治疗后血内微丝蚴减少与免疫反应变化之间的关系,可有助于阐明治疗效果的免疫学依据。
The appearance of microfilariae (mf) in peripheral blood is associated with a decrease in body fluid and cellular immune responses to filarial infections in vivo, and DECs treatment may result in significantly higher response to filarial specific antigens. It is known that the action of DEC on the production of microfilariae is dependent on host factors and has the action of killing adult filarial worms. Ivermectin is different from DEC, now that it directly kill mf, no effect on adults. For this reason, comparing the relationship between the reduction of in-blood microfilariae and the change of immune response after the above two kinds of drug treatment can be helpful to clarify the immunological basis of the treatment effect.