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对从广州市某医院儿科病房腹泻儿童粪便中检测获得的４６株产肠毒性大肠杆菌（ＥＴＥＣ）的４种遗传型（ＬＴ－ｈ、ｓＴ－ｐ、ＳＴ－ｈ和ＣＦＡ／Ｉ）菌株，用１４种常用抗生素进行敏感试验和质粒特征分析，结果：在１２４株大肠杆菌中，分别用ＥＴＥＣ的４种￣（３２）Ｐ－ＤＮＡ基因探针检测，总阳性率为３７．１０％（４６／１２４），ＳＴ－ｐ的阳性率最高，占６０．８７％（２８／４６），有三例病人分别受到２株具有不同遗传型ＥＴＥＣ感染。药物敏感试验，多数的菌株对青霉素Ｇ（１００％）、红霉素（７３．９１％）、氨苄青霉素（６９．５７％）和羧苄青霉素（６５．２２％）有抗性，８２．６１％以上的菌株对多粘菌素Ｂ、氟哌酸、庆大霉素和先锋霉素Ｖ是敏感的，４６株ＥＴＥＣ的质粒携带率为６３．０４％（２９／４６），各菌株之间的质粒图谱不尽相同，菌株的质粒携带数１－１１个不等，分子量１．１－７５．６Ｍｄ．发现抗四环素和氯霉素的菌株中，质粒的含量有显著差异（χ￣２＝１５．９９、Ｐ＜０．０１）。
Four genotypes (LT-h, sT-p, ST-h and CFA / I) of 46 strains of Enterotoxigenic Escherichia coli (ETEC) that were detected from the stool samples of children with diarrhea from a hospital pediatric ward in Guangzhou City were treated with 14 kinds of commonly used antibiotics were used for sensitivity test and plasmid characterization. Results: In 124 E.coli strains, the total positive rate of ETEC was 37.10% (46 / 124). The positive rate of ST-p was the highest, accounting for 60.87% (28/46). Three patients were infected with 2 different ETECs. Most of the strains were resistant to penicillin G (100%), erythromycin (73.91%), ampicillin (69.57%) and carbenicillin (65.22%) by drug sensitivity test, while 82.61 The strains above% were sensitive to polymyxin B, norfloxacin, gentamicin and cephalosporin V, and the plasmid carrying rate of 46 ETECs was 63.04% (29/46). Among the strains, The plasmid map varies, the strains carrying plasmid number ranging from 1-11, the molecular weight of 1.1-75.6Md. Plasmids were found to be significantly different among strains resistant to tetracycline and chloramphenicol (χ2 = 15.99, P <0.01).