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Lymphopenia has been implicated in patients infected with Severe Acute Respiratory Syndrome Coronavirus-2,while the association of Lymphocyte count and changes with subsequent the progression of COVID-19 remains unclear.The clinical and laboratory data of 228 patients with the definite outcome by February 19,2020 in the First Hospital of Changsha were reviewed.The characteristics of COVID-19 with lymphopenia patients in age distribution,underlying diseases,hospitalization,treatment and hospitalization time were analyzed.Meanwhile,we analyzed the difference between the change of lymphocyte count and the progress of the disease within 15 days.Among the 228 patients,226 (99.1 ％)were discharged and survived,and 2 (0.8％)were died.The hospitalization days (≥15)of patients with lymphopenia (77.2％)of almost three times as high as that for nonlymphopenia (23.6％)(P < 0.05 ).Compared with the non-lymphopenia,COVID-19 with lymphopenia had a higher proportion of severe patients (32.4％ vs.67.6％)(P < 0.05).Dynamic changes of lymphocyte were also closely related to the progress of COVID-19 during hospitalization.Baseline lymphocyte levels and changes were associated with subsequent progression.Monitoring lymphocyte during hospitalization may be important in the prognosis of COVID-19.