论文部分内容阅读
近年来糖尿病认知功能障碍作为一种糖尿病中枢神经系统并发症越来越受到人们的重视。糖尿病导致的中枢神经系统并发症常伴随着血脑屏障结构和功能的破坏。血脑屏障是中枢神经系统所特有的结构,对维持大脑内环境稳定以及分子转运起着重要作用。在糖尿病的病理发生发展过程中,高血糖、晚期糖基化终产物、炎性因子等诸多因素均可导致血脑屏障损伤,进而引起脑内神经元受损,从而导致认知功能障碍的发生。稳定血脑屏障可能成为治疗糖尿病认知功能障碍的主要策略之一,对血脑屏障改善糖尿病认知功能障碍以及相关中药的干预作用进行综述。
In recent years, cognitive dysfunction of diabetes as a central nervous system complications of diabetes more and more attention. Central nervous system complications caused by diabetes are often accompanied by the destruction of the structure and function of the blood-brain barrier. The blood-brain barrier is a peculiar structure of the central nervous system and plays an important role in maintaining the stability of the brain and the transport of molecules. During the pathological development of diabetes, many factors such as hyperglycemia, advanced glycation end products, inflammatory factors and other factors can lead to damage to the blood-brain barrier, thereby causing neuronal damage in the brain, resulting in cognitive dysfunction . Stabilization of the blood-brain barrier may become one of the main strategies for the treatment of cognitive dysfunction in diabetes. The effects of improving the cognitive function of the blood-brain barrier against diabetes and related Chinese medicines are reviewed.