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为了了解乙型肝炎慢性携带者的自然发展史,作者于1979年8月和1984年7月对武汉市市郊129户717人进行了二次横断调查,用RHPA、PHA和AGD分别测定了HBsAg、抗-HBs和HBeAg标记,第一次结果依次为12.55％、7.95％和3.45％;第二次复查其中的606人,结果依次为9.57％、2.48％和4.56％。HBsAg和抗-HBS的结果,1979年高于1984年,说明HBsAg和抗-HBs在稳定人群中抗原携带率和抗体水平均有下降趋势,其5年的自然阴转率HBsAg25.35％,抗-HBs 90.74％、HBeAg 54.55％,阳转率分别为0.94％、1.81％、2.70％,1979年HBs-Ag携带率的家庭聚集现象在1984年检测时有减弱趋势。
In order to understand the natural history of chronic hepatitis B carriers, the authors conducted a second transect survey of 717 people in 129 suburbs of Wuhan in August 1979 and July 1984. The RHs, PHA and AGD were used to determine the HBsAg, Anti-HBs and HBeAg markers, the first results were followed by 12.55%, 7.95% and 3.45%; the second review of 606 of them, the results were 9.57%, 2.48% and 4.56%. The results of HBsAg and anti-HBS in 1979 were higher than those in 1984, indicating that both HBsAg and anti-HBs have a decreasing trend in antigen-carrying rate and antibody level in stable population. The 5-year natural rate of negative conversion (HBsAg) is 25.35% -HBs 90.74%, HBeAg 54.55%, positive conversion rates were 0.94%, 1.81%, 2.70%, 1979, the family aggregation phenomenon of HBs-Ag carrier rate in the test in 1984 weakened trend.