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目的 :旨在进一步验证根除幽门螺杆菌与十二指肠溃疡复发之间的关系。方法 :选择经胃镜活检快速尿素酶试验阳性和病理学检查Hp阳性的十二指肠溃疡病例 ,经系统的抗Hp治疗和抗溃疡治疗后一月复查胃镜 ,溃疡愈合及Hp阴性者为A组(Hp根除溃疡组 ) ,选择经胃镜活检快速尿素酶试验阴性和病理学检查Hp阴性的十二指肠溃疡病例 ,经抗溃疡治疗后一月复查胃镜 ,溃疡愈合者为B组 (Hp阴性溃疡组 )。所有病例在停药后第一年及第二年末各复查胃镜一次 ,并取胃窦活检做快速脲酶试验及病理检查。如有症状随时来医院行胃镜检查。同时做Hp检查。观察两组病人中十二指肠溃疡的复发情况。结果 :至第二年末 ,有15 3例患者完成全部随访 ,其中Hp根除溃疡组 85例 ,Hp阴性溃疡组 68例 ,Hp根除溃疡组第一年随访时复发 5例 ,第二年随访时复发 6例 ,总复发率为 12 94% (其中 4例Hp再感染 ) ,Hp阴性溃疡组第一年随访时复发 15例 ,第二年随访时复发 17例 ,总复发率为 5 1 47% ,其中 15例复查Hp为阳性 ,Hp阴性溃疡组较Hp根除溃疡组有比较高的复发率 ( P <0 0 5 )。结论 :根除Hp能减少十二指肠溃疡的复发
Objective: To further verify the relationship between eradication of Helicobacter pylori and recurrence of duodenal ulcer. Methods: The patients with positive duodenal ulcer by positive urethral urethral biopsy and Hp positive pathological examination were enrolled. Group A was treated with systemic anti-Hp therapy and anti-ulcer treatment one month after gastroscopy, ulcer healing and Hp-negative (Hp eradication ulcer group), selected by endoscopy biopsy fast urease test negative and pathological examination of Hp-negative duodenal ulcer cases, after anti-ulcer treatment in January review of endoscopy, ulcer healing for the B group (Hp-negative ulcer group). All cases in the first year after stopping and the end of the second review of gastroscopy once, and to take fast gastric urethra urease test and pathological examination. If symptoms go to the hospital gastroscopy. Hp check at the same time. The recurrence of duodenal ulcer in both groups was observed. Results: By the end of the second year, 15 3 patients completed the follow-up. Among them, 85 were Hp eradication group, 68 Hp-negative ulcer group, 5 were Hp eradication group at the first year of follow-up, 6 cases, the total recurrence rate was 1294% (4 cases of Hp re-infection), Hp-negative ulcer group at the first year follow-up of 15 cases of recurrence, the second year of follow-up of 17 cases of recurrence, the total recurrence rate was 51.74% Among them, Hp was positive in 15 cases and Hp-ulcer group was higher than Hp-eradicated ulcer group (P <0.05). Conclusion: Eradication of Hp can reduce the recurrence of duodenal ulcer