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为研究慢性乙型肝炎患者发生肝硬化的自然过程,作者对76例慢性乙型肝炎新发肝硬化的患者进行前瞻性调查。平均随访时间34.4月,共45例病情有急性加剧,在乙型肝炎 e 抗原(HBeAg)和/或乙肝病毒-DNA(HBV-DNA)阳性患者(Ⅰ组)中,急性加剧的年发生率为25.9%,显著高于阴性组(Ⅱ组)的11.9%。临床疾病急性加剧的病原学分析主要由于 HBV 感染加剧(Ⅰ组76.5%,Ⅱ组72.9%),少数(6.7%)由于丁型肝炎病毒(HDV)感染,其它(17.8%)可
To investigate the natural course of cirrhosis in patients with chronic hepatitis B, the authors prospectively investigated 76 patients with newly diagnosed cirrhosis of chronic hepatitis B. The average follow-up time was 34.4 months, a total of 45 cases of acute exacerbations of hepatitis B e antigen (HBeAg) and / or hepatitis B virus DNA (HBV-DNA) -positive patients (Ⅰ group), the annual incidence of acute exacerbation 25.9%, significantly higher than the negative group (11.9%). The etiological analysis of the acute exacerbation of clinical disease was mainly due to an exacerbation of HBV infection (76.5% in group I and 72.9% in group II), and a minority (6.7%) due to hepatitis D virus infection (17.8%)