论文部分内容阅读
目的:为提高齐墩果酸的生物利用度,采用聚乳酸-羟基乙酸共聚物为载体材料,优选齐墩果酸纳米粒的处方与制备工艺。方法:采用纳米沉淀法制备齐墩果酸纳米粒,HPLC测定齐墩果酸含量。以包封率为指标,L9(34)正交试验设计进行处方优化。结果:制备的齐墩果酸聚乳酸-羟基乙酸共聚物纳米粒(OA-PLGA-NP)为带有蓝光的乳白胶体溶液,平均粒径129 nm,包封率88.64%。结论:该优化条件工艺简便,稳定性良好,可用于OA-PLGA-NP的制备。
OBJECTIVE: To improve the bioavailability of oleanolic acid, polylactic acid-glycolic acid copolymer was used as carrier material, and the preparation and preparation of oleanolic acid nanoparticles were optimized. Methods: Oleanolic acid nanoparticles were prepared by nano-precipitation method and the content of oleanolic acid was determined by HPLC. The entrapment efficiency as an indicator, L9 (34) orthogonal experimental design for prescription optimization. Results: The prepared oleanolic acid-glycolic acid copolymer nanoparticles (OA-PLGA-NP) was a colloidal solution of colloidal silica with blue light with average particle diameter of 129 nm and entrapment efficiency of 88.64%. Conclusion: The optimized conditions are simple, stable and can be used for the preparation of OA-PLGA-NP.