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目的 探讨星形细胞瘤微血管密度 (MVD)与病理分级的关系。方法 对磁共振成像 (MRI)术前诊断及手术病理证实的幕上星形细胞瘤石蜡标本进行免疫组化染色 ,测定MVD。结果 随着星形细胞瘤级别的增加 ,MVD值增高 ,且Ⅰ、Ⅱ级与Ⅲ、Ⅳ级之间有显著差异 (P <0 0 1) ;MVD随着肿瘤直径增大而增加 ,但无显著差异 (P >0 0 5 )。结论 MVD与星形细胞瘤恶性表型及生物学行为密切相关 ,可作为判断星形细胞瘤恶性程度的指标。
Objective To investigate the relationship between microvessel density (MVD) and pathological grade in astrocytomas. Methods Immunohistochemical staining was performed on magnetic resonance imaging (MRI) preoperative diagnosis and surgical pathologically confirmed paraffin-embedded astrocytoma paraffin specimens to determine MVD. Results With the increase of astrocytoma grade, the MVD value increased, and there was a significant difference between grades I and II and grades III and IV (P < 0.01); MVD increased with tumor diameter, but no Significant difference (P > 0 0 5). Conclusion MVD is closely related to the malignant phenotype and biological behavior of astrocytoma and can be used as an index to judge the malignancy of astrocytoma.