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最近德国科学家Burm ester等发现神经组织中存在一类携氧球蛋白,把这类主要在脑、视网膜及内分泌组织中表达的第3类携氧球蛋白称为脑红蛋白(NGB)。此蛋白可在缺氧条件下为神经组织供氧5~31 m in,且具有加速氧向神经组织转运的功能。NGB在低氧预适应过程中起重要作用:NGB的含量越低对缺氧的耐受性越差。NGB基因表达的调控至少有3条信号转导途径参与。视网膜的相对耗氧量高于全身各组织器官,缺氧将直接导致视觉传导过程的严重障碍。NGB的发现,为视网膜缺氧的研究指出了新方向,为缺氧性视网膜损伤的防治提供了新的思路。
Recently, German scientist Burm ester and others found that there is a kind of oxygen-carrying globulin in nerve tissue. These types of oxygen-carrying globins, which are mainly expressed in the brain, retina and endocrine tissue, are called as neutrophil (NGB). This protein can supply oxygen to nerve tissue for 5 to 31 minutes under hypoxic conditions and has the function of accelerating oxygen transport to nerve tissues. NGB plays an important role in hypoxic preconditioning: the lower the content of NGB, the worse its tolerance to hypoxia. Regulation of NGB Gene Expression At least 3 signal transduction pathways are involved. The relative oxygen consumption of the retina is higher than the body tissues and organs, hypoxia will directly lead to serious obstacles to the visual conduction process. The discovery of NGB has pointed out a new direction for the study of retinal hypoxia and provided a new idea for the prevention and treatment of hypoxic retinal damage.