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目的 探讨2型糖尿病（DM）胰岛素抵抗（IR）在高血压发生机制中的作用。方法 检测了60例2型DM患者及40例正常对照者的空腹血糖（FBG）、空腹胰岛素（FINS）、HbA1C、血脂、红细胞膜Na+-K+-ATP酶与Mg2+-ATP酶活性及血压等，并将DM组分为A组（IS＞0.6）及B组（IS≤0.6）。结果 2型DM患者FBG、HbA1C 、FINS、TG、TC及B组血压均显著增高，胰岛素敏感性指数（ISI）、HDLc、Na+-K+-ATP酶及Mg2+-ATP酶活性显著降低，且后两者均与ISI呈显著正相关，与FINS、SBP呈显著负相关，Na+-K+-ATP酶并与DBP呈显著负相关。与DM A组比较，DM B组以上变化更为显著。结论 2型DM存在IR。IR是导致高胰岛素血症、Na+-K+-ATP酶、Mg2+-ATP酶及脂质代谢异常的关键因素，并且后者也是IR导致血压升高及高血压的重要途径。
Objective To investigate the role of insulin resistance (IR) in type 2 diabetes mellitus (DM) in the pathogenesis of hypertension. Methods Fasting plasma glucose (FBG), fasting insulin (FINS), HbA1C, lipids, Na + -K + -ATPase and Mg2 + -ATPase activity and blood pressure were detected in 60 patients with type 2 DM and 40 healthy controls. DM group was divided into A group (IS> 0.6) and B group (IS≤0.6). Results The blood pressure of FBG, HbA1C, FINS, TG, TC and B group were significantly increased in type 2 DM patients. The activities of insulin sensitivity index (ISI), HDLc, Na + -K + -ATPase and Mg2 + -ATPase were significantly decreased Were positively correlated with ISI, negatively correlated with FINS and SBP, and negatively correlated with Na + -K + -ATPase and DBP. Compared with DM group A, DM group B more obvious changes. Conclusion Type 2 DM has IR. IR is a key factor leading to hyperinsulinemia, Na + -K + -ATPase, Mg2 + -ATPase and lipid metabolism abnormalities, and the latter is also an important way for IR to cause elevated blood pressure and hypertension.