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目的:研究应用计算机辅助系统实现主动监测住院患者万古霉素肾毒性的可行性和关键要素。方法:基于住院患者药品不良事件主动监测与评估警示系统,通过团队论证的方式设定住院患者万古霉素肾毒性主动监测的事件配置器,回顾性调取2012年10月1日–2013年8月27日我院经静脉途径应用万古霉素的住院患者,对系统提示的阳性预警病例进行人工再评价。结果:实际共筛查病例619例次,系统提示的阳性预警病例为9例次,经人工再评价的实际阳性病例为4例次,阳性预警率为0.65%。结论:住院患者药品不良事件主动监测与评估警示系统对万古霉素肾毒性的阳性预警率与文献报道结果相符,应用系统进行主动监测研究中事件配置器的参数设置为关键要素,应基于不同目标药物和药品不良事件特点进行个体化设置。
Objective: To study the feasibility and key elements of using computer-aided system to actively monitor vancomycin nephrotoxicity in hospitalized patients. Methods: Based on the active monitoring and evaluation alert system for adverse drug events in hospitalized patients, the event configurator for active monitoring of vancomycin nephrotoxicity in hospitalized patients was set up by means of team demonstration, and retrospectively taken from October 1, 2012 to August 2013 On January 27, our hospital was treated with vancomycin via intravenous route, and then artificial re-evaluation was performed on the positive alert system prompted by the system. Results: There were 619 co-screening cases in total. The number of positive warnings prompted by the system was 9, and the actual number of positive re-evaluation cases was 4, with a positive rate of 0.65%. Conclusion: The positive warning rate of vancomycin nephrotoxicity in active monitoring and evaluation of adverse events of inpatients is consistent with the reported results. The parameter setting of event configurator in active monitoring research should be based on different goals Drug and drug adverse event characteristics of individual settings.