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目的探讨冠心病患者血脂及载脂蛋白水平对冠心病的诊断价值。方法冠状动脉造影阳性的患者为冠心病组(A组,80例);其中,单支病变亚组36例(A1组),多支病变亚组44例(A2组)。冠状动脉造影阴性的患者为对照组(C组,75例)。测定各组血清总胆固醇(TC)、低密度脂蛋白-胆固醇(LDL-C)、高密度脂蛋白-胆固醇(HDL-C)、甘油三酯(TG)、脂蛋白a(Lpa)、载脂蛋白AI(ApoAI)、载脂蛋白B(ApoB),计算ApoB与ApoAI的比值(ApoB/ApoAI)。结果 A组ApoB水平和ApoB/ApoAI比值均高于C组[(0.74±0.18)g/L vs.(0.66±0.16)g/L和(0.67±0.19)vs.(0.60±0.19)](P<0.05)。A2组LDL-C水平高于A1组[(3.05±0.84)mmol/L vs.(2.55±0.75)mmol/L](P<0.05)。结论 ApoB水平及ApoB/ApoAI比值对于冠心病的诊断具有一定的临床意义;LDL-C水平对于判断冠脉病变的范围则有一定的价值。
Objective To investigate the diagnostic value of serum lipids and apolipoproteins in coronary heart disease in patients with coronary heart disease. Methods Coronary angiography was performed in patients with coronary heart disease (group A, n = 80). Among them, 36 patients in the single-vessel disease group (group A1) and 44 patients in the multi-vessel disease group (group A2). Coronary angiography negative patients for the control group (C group, 75 cases). The levels of total cholesterol (TC), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), triglyceride (TG), lipoprotein (Lpa) Protein AI (ApoAI), apolipoprotein B (ApoB) were calculated and the ratio of ApoB to ApoAI (ApoB / ApoAI) was calculated. Results The ApoB level and ApoB / ApoAI ratio in group A were significantly higher than those in group C [(0.74 ± 0.18) g / L vs. (0.66 ± 0.16) g / L and (0.67 ± 0.19) vs. (0.60 ± 0.19) <0.05). The level of LDL-C in A2 group was higher than that in A1 group [(3.05 ± 0.84) mmol / L vs. (2.55 ± 0.75) mmol / L] (P <0.05). Conclusions ApoB level and ApoB / ApoAI ratio have some clinical significance for the diagnosis of coronary heart disease. The level of LDL-C has some value for judging the extent of coronary artery disease.