干扰素γ(IFN-γ)是具有广谱抗病毒、免疫调节和抗增殖作用的炎性细胞因子。在肝脏中,IFN-γ可以引起肝细胞的细胞周期阻滞和细胞凋亡。这些生理过程主要是对肝脏起到保护作用,但是在长期的肝病中就可能会导致致癌基因的突变。文章就IFN-γ的结构特点、受体及信号通路,以及对肝细胞周期及凋亡的影响进行了综述。 Interferon gamma (IFN-γ) is an inflammatory cytokine that has a broad spectrum of anti-viral, immunomodulatory and antiproliferative effects. In the liver, IFN-γ causes cell cycle arrest and apoptosis in hepatocytes. These physiological processes are mainly protective of the liver, but in the long-term liver disease may lead to oncogenic mutations. This review summarizes the structural features of IFN-γ, its receptors and signaling pathways, and the effects on hepatocyte cycle and apoptosis.