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将8名甲肝抗体阴性的6—8岁学龄儿童按常规种痘方法接种含甲肝病毒基因的重组痘苗病毒。接种后一个月痘苗与甲肝抗体全部阳转。免疫后二月甲肝抗体滴度为1:4～≥1:16,平均1:8(ELISA竞争抑制法)。中和抗体滴度为1:10～1:80。免后二年甲肝抗体仍保持阳性,滴度稍有下降。两年期间免疫儿童未发生甲肝病例;对照组8名儿童中1名患甲肝,另一名隐性感染。
Eight hepatitis A antibody-negative school-age children aged 6-8 were vaccinated with the recombinant vaccinia virus containing the hepatitis A virus gene according to the conventional vaccination method. One month after inoculation vaccinia and hepatitis A antibody all positive. February antibody hepatitis B antibody titer 1: 4 ~ 1: 16, an average of 1: 8 (ELISA competitive inhibition). The titer of neutralizing antibody was 1:10 ~ 1:80. Hepatitis A antibody remained positive after two years of inoculation with a slight decrease in titer. Hepatitis A cases did not occur in immunized children during the two years; one of the eight children in the control group had hepatitis A and the other had a latent infection.