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目的 观察中剂量特尔立（ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ）对恶性肿瘤化疗后白细胞减少的防治作用。方法 采用自身对照，化疗过程中白细胞降至正常值（４０×１０９／ Ｌ）以下时入组，并作为对照周期。其后的化疗周期中末次给药 ４８ 小时后皮下注射ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ（１５０ｕｇ／（次·天）。结果 ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ能明显减轻化疗后白细胞下降的程度，缩短白细胞在正常值以下的持续时间及恢复到正常值以上的时间，对血小板的变化影响不大，毒副反应轻微。结论 使用特尔立（ｒｈ Ｇ Ｍ Ｃ Ｓ Ｆ）安全、有效，可作为肿瘤化疗有价值的辅助药物。
Objective To observe the preventive and therapeutic effects of rh G M C S F on leukopenia after chemotherapy in malignant tumors. Methods Self-control was used. During the course of chemotherapy, leukocytes were reduced to normal values (40×109/L) and were included in the group as a control period. In the subsequent cycle of chemotherapy, rhG M C S F was injected subcutaneously 48 hours after the last administration (150 ug/(second day). Results rh G M C S F can significantly reduce the degree of leukopenia after chemotherapy and shorten leukocytes. The duration below the normal value and the recovery time above the normal value had little effect on the change of platelet and the toxicity was mild.Conclusion The use of rh G M C S F is safe and effective as a tumor. A valuable adjuvant drug for chemotherapy.