Background Anomalous Origin of Coronary Artery(AOCA), a congenital heart disease with low incidence,can cause sudden cardiac death in the young. It’s surgical treatment is scarcely performed in clinical practice,thus the special nursing needed during the surgery for this rare disease is largely unrecognized. Method There were 7 adult patients who had suffered from AOCA received corrective operation in our hospital in the last 10 years. Preoperative preparation, nursing cooperation and emergency procedure were analyzed and summarized.Result The AOCA corrective surgery was all successfully completed on these 7 patients. The nursing key points were drawn from these patients. Conclusion Key points of nursing cooperation in AOCA correction surgery include: understanding the condition, mastering pathological anatomy preoperative, making strict application of gradient temperature control,observing the change of the disease, and carrying out all kinds of emergency preparation during surgery. Meanwhile, careful check in all cases and literature data, participate in preoperative discussion, and skilled techniques are also important to the success of surgery. Background Anomalous Origin of Coronary Artery (AOCA), a congenital heart disease with low incidence, can cause sudden cardiac death in the young. It’s surgical treatment is scarcely performed in clinical practice, thus the special nursing needed during the surgery for this rare disease is largely unrecognized. Method There were 7 adult patients who had suffered from AOCA received corrective operation in our hospital in the last 10 years. Preoperative preparation, nursing cooperation and emergency procedure were analyzed and summarized. Result The AOCA corrective surgery was all successfully completed on these 7 patients. The nursing key points were drawn from these patients. Conclusion Key points of nursing cooperation in AOCA correction surgery include: understanding the condition, mastering pathological anatomy preoperative, making strict application of gradient temperature control, observing the change of the disease, and carrying out all kinds of emergency preparation during surgery. M eanwhile, careful check in all cases and literature data, participate in preoperative discussion, and skilled techniques are also important to the success of surgery.