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对龙胆科Gentianaceae獐牙菜属植物贵州獐牙菜Swertia kouitchensis 90%乙醇提取物乙酸乙酯萃取部分的化学成分进行研究。利用各种柱色谱方法对其进行分离纯化,通过波谱数据分析(1H-NMR,13C-NMR,MS)进行结构鉴定。从中分离鉴定了28个化合物,包括6个裂环烯醚萜、2个酮及其苷、3个少见的内酯烯胺酮、2个三萜、1个木质素和14个其他类化合物,分别为红白金花内酯(erythrocentaurin,1)、erythrocentaurin dimethylacetal(2)、獐牙菜苦苷(swertiamarin,3)、vogeloside(4)、2’-O-actylswertiamarin(5)、狭叶獐牙菜苷D(swertianoside D,6)、獐牙菜烯胺酮A~B(gentiocrucines A~B,7~8)、gentiocrucine(9)、1-羟基-3,7,8-三甲氧基酮(1-hydroxy-3,7,8-trimethoxyxanthone,10)、1-羟基-3,5,6-三甲氧基酮(1-hydroxy-3,5,6-trimethoxyxanthone,11)、3-表-蒲公英赛醇(3-epitaraxerol,12)、erythrodiol 3-O-palmitate(13)、(+)-丁香脂素((+)-syringaresinol,14)、咖啡酸(caffeic acid,15)、松柏醛(trans-coniferyl aldehyde,16)、松柏醇(trans-coniferyl alcohol,17)、3,4-二羟基苯甲酸(3,4-dihydroxybenzoic acid,18)、4-羟基-3-甲氧基苯甲酸(4-hydroxy-3-methoxybenzoic acid,19)、3,4-二羟基苯甲醛(3,4-dihydroxybenzoic aldehyde,20)、2,3-二羟基苯甲酸(2,3-dihydroxybenzoic acid,21)、对羟基苯甲酸(4-hydroxybenzoic acid,22)、3-乙酰氧基苯甲酸(3-acetoxybenzoic acid,23)、间羟基苯甲酸(3-hydroxybenzoic acid,24)、间羟基苯甲醇(3-hydroxybenzoic alcohol,25)、烟酸(nicotinic acid,26)、2-糠酸(2-furoic acid,27)、尿嘧啶(uracil,28)。其中化合物1~4,6~28为首次从贵州獐牙菜中分离得到。
The chemical constituents of 90% ethanol extract of ethyl acetate extract of Gentianaceae Swertia kouitchensis were studied. The compounds were separated and purified by various column chromatography and identified by spectral data analysis (1H-NMR, 13C-NMR, MS). A total of 28 compounds were isolated and identified, including 6 sirtuins, 2 stilbenes and their glycosides, 3 rare lactone amines, 2 triterpenoids, 1 lignin and 14 other classes The compounds were erythrocentaurin (1), erythrocentaurin dimethylacetal (2), swertiamarin (3), vogeloside (4), 2’-O-actylswertiamarin Swertianoside D (6), gentiocrucines A ~ B (7 ~ 8), gentiocrucine (9), 1-hydroxy-3,7,8-trimethoxy 1-hydroxy-3,7,8-trimethoxyxanthone (10), 1-hydroxy-3,5,6-trimethoxyxanthone (11), 3 - Table - 3-epitaraxerol (12), erythrodiol 3-O-palmitate (13), (+) - syringaresinol, 14), caffeic acid Trans-coniferyl aldehyde (16), trans-coniferyl alcohol (17), 3,4-dihydroxybenzoic acid (18), 4- hydroxy-3-methoxy 4-hydroxy-3-methoxybenzoic acid (19), 3,4-dihydroxybenzoic aldehyd e, 20), 2,3-dihydroxybenzoic acid (21), 4-hydroxybenzoic acid (22), 3-acetoxybenzoic acid 23, 3-hydroxybenzoic acid (24), 3-hydroxybenzoic alcohol (25), nicotinic acid (26) and 2-furoic acid (27) , Uracil (28). Compounds 1 ~ 4,6 ~ 28 were isolated from Guizhou Swertia for the first time.