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目的研究人乳头状瘤病毒(HPV)感染与鼻内翻性乳头状瘤(NIP)的发病以及恶变关系的相关性。方法选择自河北港口集团有限公司港口医院2010年9月-2012年1月的69例鼻内翻性乳头状瘤患者,将患者按照病理学检查分为不伴恶变组(41例),伴恶变组(28例),选择同时期的32例鼻息肉患者作为对照组,采用多聚酶链反应(PCR)技术,对HPV6、HPV16、HPV11以及HPV18四个型别的HPV-DNA进行检测。结果 69例NIP患者的HPV-DNA总阳性率为62.32%(43/69),不伴有恶变的组中HPV-DNA的阳性率为56.10%(23/41),伴有恶变组的HPV-DNA阳性率为71.43%(20/28),恶变组与不伴恶变组HPV-DNA阳性率差异无统计学意义(χ2=1.66,P>0.05),对照组无一例阳性结果出现,比较差异有统计学意义(χ2=34.73,P<0.01)。在检出的43例HPV-DNA阳性患者中,以HPV16、HPV18为主,分别占39.53%和48.84%。结论人乳头状瘤病毒在鼻内翻性乳头状瘤的发病中有重要的影响作用,其中人乳头状瘤16、18型与鼻内翻乳头状瘤的恶变具有相关性,值得进一步研究确认。
Objective To study the relationship between human papillomavirus (HPV) infection and the pathogenesis of nasal inverted papilloma (NIP) and their relationship to malignant transformation. Methods From September 2010 to January 2012, 69 cases of nasal inverted papilloma were selected from Port Hospital of Hebei Port Group Co., Ltd. Patients were divided into malignant group (41 cases) and non-malignant group (41 cases) according to pathological examination. (N = 28). 32 patients with nasal polyps were selected as the control group. HPV-DNA of HPV6, HPV16, HPV11 and HPV18 were detected by polymerase chain reaction (PCR). Results The positive rate of HPV-DNA in 69 patients with NIP was 62.32% (43/69). The positive rate of HPV-DNA in non-malignant group was 56.10% (23/41) The positive rate of DNA was 71.43% (20/28). There was no significant difference in HPV-DNA positive rate between malignant group and non-malignant group (χ2 = 1.66, P> 0.05), but no positive result was found in the control group Statistical significance (χ2 = 34.73, P <0.01). Of the 43 HPV-DNA positive patients detected, HPV16 and HPV18 were the major components, accounting for 39.53% and 48.84% respectively. Conclusions Human papillomavirus plays an important role in the pathogenesis of nasal inverted papilloma, of which human papilloma type 16 and 18 are correlated with the malignant transformation of nasal papilloma, which deserves further study and confirmation.