目的检测蝎毒、蝎毒多肽对家兔和小鼠凝血功能的影响。方法分别采用目测法、镜检计数法、血液学分析仪测定家兔和小鼠的出血时间、凝血时间、血小板计数及血浆纤维蛋白原,分析其注射蝎毒、蝎毒多肽前后的变化。结果二者均能使出、凝血时间延长,血小板数量降低,血浆纤维蛋白原减少。蝎毒多肽降低血小板数目和血浆纤维蛋白原含量的作用强于蝎毒。结论蝎毒多肽对凝血系统的影响大于蝎毒。 Objective To detect the effect of scorpion venom and scorpion venom on coagulation in rabbits and mice. Methods The rabbits and mice were measured for bleeding time, clotting time, platelet count, and plasma fibrinogen by visual inspection, microscopy counting, and hematology analyzer, and the changes before and after injection of scorpion venom and scorpion venom peptides were analyzed. Results Both resulted in prolonged clotting time, reduced platelet counts, and decreased plasma fibrinogen. The role of scorpion venom peptides in reducing platelet counts and plasma fibrinogen levels is stronger than that of scorpion venom. Conclusion The scorpion venom peptide has more influence on the coagulation system than scorpion venom.