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目的:探讨急性冠状动脉综合征(ACS)患者血清脑钠肽(BNP)水平与其冠状动脉病变严重程度及心脏功能的关系。方法:ACS患者81例,分为不稳定型心绞痛(UAP组)组39例和急性心肌梗死组(AMI)组42例,于入院后即刻检测血清BNP水平,并检查冠状动脉病变情况和左室射血分数,分析BNP的水平与冠状动脉病变、心脏功能之间的关系。结果:血清BNP水平随着病情的加重而逐渐升高,AMI组明显高于UAP组,并且从单支病变、双支病变到3支病变BNP水平逐渐增高,两者呈正相关(rs=0.813,P<0.01);随着左室射血分数的降低,BNP水平逐渐升高,两者呈负相关(rs=-0.846,P<0.01)。结论:血清BNP水平与冠状动脉病变程度及心功能相关,可用于ACS患者的危险评估。
Objective: To investigate the relationship between serum brain natriuretic peptide (BNP) level and the severity of coronary artery disease and cardiac function in patients with acute coronary syndrome (ACS). Methods: Eighty-one ACS patients were divided into unstable angina (UAP group) group (39 cases) and AMI group (42 cases). Serum BNP levels were measured immediately after admission and coronary artery disease and left ventricular Ejection fraction, analysis of the level of BNP and coronary artery disease, the relationship between heart function. Results: Serum BNP levels gradually increased with the severity of the disease. The AMI group was significantly higher than the UAP group. The level of BNP increased from single vessel disease to double vessel disease to 3 vessel disease, with a positive correlation (r = 0.813, P <0.01). BNP levels gradually increased with the decrease of left ventricular ejection fraction (r = -0.846, P <0.01). Conclusion: Serum BNP level is related to the degree of coronary artery disease and cardiac function, and can be used to evaluate the risk of ACS.