论文部分内容阅读
肥胖是一种常见的营养代谢紊乱,由于其与许多慢性疾病如非胰岛素依赖型糖尿病(NIDD)、高血压、高血脂、中风和一些肿瘤等相关密切,已成为一个严重的公共卫生问题。肥胖是能量代谢失衡的结果。哺乳动物的能量平衡被认为是脂肪代谢产物、血糠水平和体温等通过下丘脑反馈调节饮食和能量代谢而维持稳定。但这些理论不能准确地解释体内调节能量代谢的机制。1994年,Zhang等成功地克隆了ob基因,编码16KD蛋白质激素Leptin,Leptin在体内由脂肪细胞产生,其与下丘脑的受体结合,通
Obesity is a common nutritional and metabolic disorder that has become a serious public health problem due to its close association with many chronic diseases such as non-insulin-dependent diabetes mellitus (NIDD), hypertension, hyperlipidemia, stroke and some tumors. Obesity is the result of an imbalance in energy metabolism. Energy balance in mammals is considered as fat metabolites, blood bran levels and body temperature through hypothalamus feedback to regulate diet and energy metabolism and maintain stability. However, these theories do not accurately explain the mechanism by which energy metabolism is regulated in the body. In 1994, Zhang et al. Successfully cloned the ob gene, encoding a 16KD protein hormone Leptin, which is produced in vivo by adipocytes and binds to receptors in the hypothalamus.