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目的观察高压氧治疗急性脑梗死的临床疗效和不良反应。方法选择发病1周内的急性脑梗死患者80例,并随机分为高压氧组和对照组各40例;对照组接受脑梗死常规药物治疗,高压氧组在对照组治疗的基础上给予高压氧治疗,氧舱压力2.0ATA,加压20min,戴面罩吸纯氧1h,中间休息10min,减压30min,共2h,1次/d,每次2h,连续治疗10d;治疗前及治疗后第7、14、21d采用欧洲卒中量表(ESS)评定患者神经功能,并观察治疗过程中的不良反应。结果2组在治疗后第14、21d与治疗前比较ESS评分均有明显增高(P<0.05);高压氧组神经功能评分ESS在治疗后第7、14d与对照组比较差异无显著性(P>0.05),在治疗后第21d优于对照组,差异有显著性(P<0.05);高压氧组无特殊不良反应。结论高压氧治疗能促进急性脑梗死患者神经功能恢复,是一种安全有效的治疗方法。
Objective To observe the clinical effects and adverse reactions of hyperbaric oxygen therapy for acute cerebral infarction. Methods Eighty patients with acute cerebral infarction within 1 week after onset were randomly divided into hyperbaric oxygen group (n = 40) and control group (n = 40). The control group received routine drug treatment of cerebral infarction. Hyperbaric oxygen group was given hyperbaric oxygen Treatment, oxygen chamber pressure 2.0ATA, pressure 20min, wearing mask inhalation of pure oxygen 1h, the middle of the rest 10min, decompression 30min, a total of 2h, 1 time / d, each 2h, continuous treatment 10d; before treatment and after treatment 7 , 14,21d used the European Stroke Scale (ESS) to evaluate the neurological function of patients, and observed the adverse reactions in the course of treatment. Results The ESS scores of the two groups were significantly increased at the 14th and 21th days after treatment compared with those before treatment (P <0.05). There was no significant difference in ESS score between the 7th and 14th day after treatment in the hyperbaric oxygen group > 0.05), and the difference was significant at 21 d after treatment (P <0.05). There was no specific adverse reaction in hyperbaric oxygen group. Conclusion Hyperbaric oxygen therapy can promote neurological recovery in patients with acute cerebral infarction, which is a safe and effective treatment.