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目的分析大血管病性脑梗死(LVD)与腔隙性脑梗死(SVD)发病因素的差异。方法检测2002年10月至2006年5月北京丰台医院100例腔隙性脑梗死患者和104例大血管脑梗死患者发病时血压和血浆纤维蛋白原(Fg)。禁食12h 后检测24 h 内空腹血糖(FPG)、C-反应蛋白(CRP)、三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白(HDL)和低密度脂蛋白(LDL)。结果 LVD 与 SVD 之间收缩压(SBP)、FPG 与 Fg 差异均有显著性意义(P 均<0.05)。性别、舒张压(DBP)、CRP、TC、TC、HDL 和 LDL 两组间差异无显著性意义(P 均>0.05)。结论高血压和高纤维蛋白原可能对 LVD 的发病起促进作用,而糖尿病患者并发 SVD 的机率可能增高。
Objective To analyze the difference of the pathogenesis of large-vessel-type cerebral infarction (LVD) and lacunar infarction (SVD). Methods Blood pressure and plasma fibrinogen (Fg) were measured in 100 patients with lacunar infarction and 104 patients with large cerebral infarction in Fengtai Hospital, Beijing from October 2002 to May 2006. Fasting blood glucose (FPG), C-reactive protein (CRP), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL) and low density lipoprotein (LDL) . Results The systolic blood pressure (SBP), FPG and Fg between LVD and SVD were significantly different (all P <0.05). There were no significant differences in gender, DBP, CRP, TC, TC, HDL and LDL between the two groups (all P> 0.05). Conclusions Hypertension and high fibrinogen may promote the pathogenesis of LVD, while the incidence of SVD in diabetic patients may be increased.