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慢淋(CLL)急变极为罕见。曾有报告CLL340例仅见2例急变,1例为急粒变,另1例不能确定细胞类型。2例均曾接受放疗,认为放射引起急变。另有报告2例CLL急变后的原始细胞有与慢淋细胞相同的膜免疫球蛋白,认为是细胞株演化而产生新的白血病过程。作者报告CLL急变7例,认为此7例与上述两种情况不同,其特征是渐进性加剧,治疗反应越来越差。7例中6例在1.25～4年观察期间发生“幼淋样”变。临床表现为进行性脾和/或淋巴结肿大(5例);1例因已施行脾切除术表现为淋巴细胞数增高和血红蛋白下降;另1例有迅速肿大的主动脉房肿块和骨髓衰竭被认为早已在急变中。“幼淋样”
CLL rapid change is extremely rare. CLL340 cases have been reported only 2 cases of acute change, 1 case of acute granulomatosis, the other case can not determine the cell type. Two patients had received radiotherapy, that radiation caused an emergency. Another report of 2 cases of CLL blast crisis after the original cells have the same with the CLL immunoglobulin, cell lines that are evolved to produce new leukemia process. The authors report 7 cases of acute CLL, suggesting that these 7 cases are different from the above two cases, characterized by progressive increase, the treatment response is getting worse. Six of the seven patients developed a “young shower” change during the 1.25-2.4 year observation period. The clinical manifestations were progressive splenomegaly and / or lymphadenopathy (n = 5). One patient had an increase in lymphocyte count and hemoglobin due to splenectomy, and the other had rapidly enlarged aortic lumps and bone marrow failure It is considered already in rapid change. “Baby shower sample”